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Publications & Presentations

Publications

Lao PJ, Handen BL, Betthauser TJ, Cohen AD, Tudorascu DL, Stone CK, Price JC, Johnson SC, Klunk WE, Christian BT. Imaging Neurodegeneration in Down Syndrome: Brain Templates for Amyloid Burden and Tissue Segmentation. Brain Imaging and Behavior (Under Review). [Down Syndrome Brain Template image]

Lao PJ, Handen BL, Betthauser TJ, Mihaila I, Hartley SL, Cohen AD, Tudorascu DL, Bulova PD, Lopresti BJ, Tumuluru RV, Murali D, Mathis CA, Barnhart TE, Stone CK, Price JC, Devenny DA, Mailick MR, Klunk WE, Johnson SC, Christian BT. Longitudinal changes in amyloid PET and volumetric MRI in the non-demented Down syndrome population. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring. 23(9):1-9, 2017. PMCID: PMC5454131.

Mihaila I, Hartley SL, Handen BL, Bulova PD, Tumuluru RV, Devenny DA, Johnson SC, Lao PJ, Christian BT (2017). Leisure Activity in Middle-Aged and Older Adults with Down Syndrome. Intellectual and Developmental Disabilities, 55(2), 97-109. PMCID: PMC5580086.

Hartley SL, Handen BL, Devenny DA, Hardison R, Mihaila I, Price JC, Cohen AD, Klunk WE, Mailick MR, Johnson SC, Christian BT. Cognitive Decline and Brain Amyloid-β Accumulation across 3-years in Adults with Down Syndrome. Neurobiology of Aging. 58:68-76, 2017. PMCID: PMC5581712

Lao PJ, Handen BL, Betthauser TJ, Mihaila I, Hartley SL, Cohen AD, Tudorascu DL, Bulova PD, Lopresti BJ, Tumuluru RV, Murali D, Mathis CA, Barnhart TE, Stone CK, Price JC, Devenny DA, Johnson SC, Klunk WE, Christian BT. Alzheimer-like pattern of hypometabolism emerges with elevated amyloid burden in Down syndrome. Neurobiology of Aging. In Press (accepted on 9/19/17).

Lao PJ, Betthauser TJ, Hillmer AT, Price JC, Klunk WE, Mihaila I, Higgins AT, Bulova PD, Hartley SL, Hardison R, Tumuluru RV, Murali D, Mathis CA, Cohen AD, Barnhart TE, Devenny DA, Mailick MR Johnson SC, Handen BL, Christian BT. The effects of normal aging on amyloid-β deposition in a population of nondemented adults with Down syndrome as imaged by [11C]PiB. Alzheimer’s & Dementia. 12(4):380-390, 2016. PMCID: PMC4677061.

Hartley SL, Handen BL, Devenny DA, Hardison R, Mihaila I, Price JC, Cohen AD, Klunk WE, Mailick MR, Johnson SC, Christian BT. Cognitive functioning in relation to brain β-amyloid in healthy adults with Down syndrome. Brain. 137:2556-2563, 2014. PMCID: PMC4189400.

Hartley SL, Handen BL, Devenny DA, Hardison R, Mihaila I, Price JC, Cohen AD, Klunk WE, Mailick MR, Johnson SC, Christian BT. (2014) Cognitive functioning in relation to brain amyloid-β in healthy adults with Down syndrome. Brain. Jul 2.

Handen B, Cohen A, Umapathy C, Bulova P, Cannon SA, Cohen WI, Mathis CA, Price JC, Klunk WE. (2012) Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B. Alzheimer's & Dementia, 8(6):496-501. doi:10.1016/j.jalz.2011.09.229

Presentations

PJ Lao, TJ Betthauser, AT Hillmer, JC Price, WE Klunk, I Mihaila, AT Higgins, PD Bulova, SL Hartley, R Hardison, RV Tumuluru, D Murali, CA Mathis, AD Cohen, TE Barnhart, DA Devenny, MR Mailick, SC Johnson, BL Handen, BT Christian. Imaging age-related effects on amyloid-βdeposition in nondemented adults with Down syndrome using [11C]PiB. Human Amyloid Imaging (HAI) meeting was January 14-16, 2015 Miami, Florida

Christian BT, Barnhart TE, Bulova PD, Devenny D, Hardison RM, Hillmer AT, Johnson SC, Klunk WE, Mathis CA, Murali D, Price JC, Seltzer MM, Wooten DW, Handen BL. Increasing Amyloid Burden with Age in Individuals with Down Syndrome. 7th Human Amyloid Imaging, Miami, FL, Jan. 16-18, 2013.

Handen B. Amyloid imaging studies in adults with Down syndrome. Presented at the Annual Meeting of the International College of Geriatric Psychoneuropharmacology, Pittsburgh, PA, October 2013.

Bulova P, Barnhart T, Christian B, Devenny D, Hardison R, Hartley S, Hillmer A, Johnson S, Klunk WE, Mathis CA, Murali D, Price JC, Seltzer MM, Wooten D, Handen B. (2013, July). The Correlation of cognitive changes and imaging brain amyloid in adults with Down syndrome using Pittsburgh compound B. Poster presented at the National Down Syndrome Medical Interest Group Meeting, Denver, CO.

Handen, B, Christian, B, Hartley, S, Devenny D, Price, JC, Mathis, CA, Seltzer, M, Johnson, S, Klunk, WE. (2013, July). Natural history of brain amyloid in non-demented adults with Down syndrome. Poster presented at the Alzheimer's Association International Conference, Boston, MA.

Handen, B, Hartley, S, Devenny D, Christian, B, Price, JC, Mathis, CA, Seltzer, M, Johnson, S, Klunk, WE. (2013, July). Neuropsychological profiles of asymptomatic adults with Down syndrome evidencing amyloid deposition. Poster presented at the Alzheimer's Association International Conference, Boston, MA.

Handen, B. (2013, April). Imaging Molecules for Studies of Alzheimer's Disease in Down Syndrome. Read before the National Institutes of Health meeting on Advancing Treatments for Alzheimer's Disease in Individuals with Down Syndrome, Potomac, MD.

Hartley S, Handen B, Christian B, Murray PJ, Price J, Johnson J, Klunk W, Devenny D. (2012, March). Preclinical stage of Alzheimer's disease: The neuropsychological profile of asymptomatic adults with Down syndrome evidencing amyloid deposition. Poster presented at the Gatlinburg Conference, Annapolis, MD.

Cohen AD, Christian B, Handen B, Johnson S, Hartley S, Seltzer M, Murali D, Bergnic M, Matan C, Price JC, Mathis CA, Klunk WE. (2011, July). Imaging brain amyloid in non-demented young adults with Down syndrome using PiB-PET. Poster presented at the Int. Conference on Alzheimer's Disease and Related Disorders, Paris, France.

Price JC, Christian B, Handen B, Johnson S, Hartley S, Seltzer M, Murali D, Bulova P, Bergnic M, Matan C, Mathis CA, Klunk WE. (2011, December). Assessing Amyloid Load in Non-demented Young Adults with Down Syndrome. Poster presented at the annual meeting of the American College of Neuro-psychopharmacology, Waikoloa Beach, Hawaii.